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Acteur Pierre OUDET

Coordonnées

Pr Pierre OUDET

Cancéropôle du Grand-Est, Coordination du Cancéropôle
Hôpital de Hautepierre - Avenue Molière - 67200 Strasbourg
Tel : +33 3 88 12 71 28, Fax : +33 3 88 12 82 83, e/m : pierre.oudet@canceropole-ge.org

Affiliation
Aires d'expertise
Cancer, Cancer:Colorectal, Clinique, Clinique:Biochimie et Biologie Moléculaire, Recherche, Recherche:Biologie Moléculaire
Projets
Comme principal investigateur
Ouvrir2007 - PROCAN-CGE (porteur : Pierre OUDET)
PROGRAMME 2007-2010- CANCEROPOLE du GRAND-EST
Ouvrir2003 - CGE en Emergence (porteur : Pierre OUDET)
CANCEROPÔLE GRAND-EST EN EMERGENCE - DES REGISTRES A LA RECHERCHE ET EVALUATION DES TRAITEMENTS

Ouvrir2009 - NADR (porteur : Evanthia SOUTOGLOU)
Nuclear architecture and chromatin structure in genome integrity and DNA repair
Ouvrir2007 - H1PVRNAI (porteur : Antonio Marchini)
Exploring the early steps of infection of H-1 oncolytic parvovirus
Publications
  • Ouvrir Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, Oudet P, Seiler R, Thalman GN, Roggero E, Sarti M, Pinton S, Mello-Grand M, Chiorino G, Catapano CV, Carbone GM, Bonapace IM. The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression. Oncogene. 2012 Nov 15;31(46):4878-87. doi: 10.1038/onc.2011.641. Epub 2012 Feb
  • Ouvrir Gaiffe E, Pretet JL, Launay S, Jacquin E, Saunier M, Hetzel G, Oudet P, Mougin C. Apoptotic HPV positive cancer cells exhibit transforming properties. PLoS One. 2012;7(5):e36766. Epub 2012 May 4.
  • Ouvrir Guerin E, Raffelsberger W, Pencreach E, Maier A, Neuville A, Schneider A, Bachellier P, Rohr S, Petitprez A, Poch O, Moras D, Oudet P, Larsen AK, Gaub MP, Guenot D. In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1alpha target genes and decreases tumor angiogenesis. Mol Med. 2012 Feb 10;18(1):83-94. doi: 10.2119/molmed.2011.00120.
  • Ouvrir Neuville A, Nicolet C, Meyer N, Schneider A, Legrain M, Brigand C, Duclos B, Bachellier P, Oudet P, Bellocq JP, Kedinger M, Gaub MP, Guenot D. Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. Hum Pathol. 2011 Feb;42(2):244-53.
  • Ouvrir Lavaux T, Bilbault P, Launoy A, Gaub MP, Oudet P, Schneider F. Interleukin-10 gene down-expression in circulating mononuclear cells during infusion of drotrecogin-alpha activated: a pilot study. Crit Care. 2010;14(5):R163. Epub 2010 Sep 8.
  • Ouvrir Budin G, Dimala MM, Lamour V, Oudet P, Mioskowski C, Meunier S, Brino L, Wagner A. A chemical labeling strategy for proteomics under nondenaturing conditions. Chembiochem. 2010 Jan 4;11(1):79-82.
  • Ouvrir Chamouard P, Monneaux F, Richert Z, Voegeli AC, Lavaux T, Gaub MP, Baumann R, Oudet P, Muller S. Diminution of Circulating CD4+CD25 high T cells in naive Crohn's disease. Dig Dis Sci. 2009 Oct;54(10):2084-93. Epub 2008 Dec 3.
  • Ouvrir Beau-Faller M, Legrain M, Voegeli AC, Guerin E, Lavaux T, Ruppert AM, Neuville A, Massard G, Wihlm JM, Quoix E, Oudet P, Gaub MP. Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping. Br J Cancer. 2009 Mar 24;100(6):985-92.
  • Ouvrir Pencreach E, Guerin E, Nicolet C, Lelong-Rebel I, Voegeli AC, Oudet P, Larsen AK, Gaub MP, Guenot D. Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clin Cancer Res. 2009 Feb 15;15(4):1297-307. Epub 2009 Feb 3.
  • Ouvrir Ruppert AM, Beau-Faller M, Neuville A, Guerin E, Voegeli AC, Mennecier B, Legrain M, Molard A, Jeung MY, Gaub MP, Oudet P, Quoix E. EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up. Eur Respir J. 2009 Feb;33(2):436-40.
  • Ouvrir Delagoutte B, Lallous N, Birck C, Oudet P, Samama JP. Expression, purification, crystallization and preliminary crystallographic study of the SRA domain of the human UHRF1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt
  • Ouvrir Papait R, Pistore C, Grazini U, Babbio F, Cogliati S, Pecoraro D, Brino L, Morand AL, Dechampesme AM, Spada F, Leonhardt H, McBlane F, Oudet P, Bonapace IM. The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin. Mol Biol Cell. 2008 Aug;19(8):3554-63. Epub 2008 May 28.
  • Ouvrir Beau-Faller M, Ruppert AM, Voegeli AC, Neuville A, Meyer N, Guerin E, Legrain M, Mennecier B, Wihlm JM, Massard G, Quoix E, Oudet P, Gaub MP. MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naive cohort J Thorac Oncol. 2008 Apr;3(4):331-9.
  • Ouvrir Vassal G, Borella L, Pierre A, Pamphile R, Bourrie B, Meflah K, Amalric F, Pauporte I, Caillot JL, Formstecher P, Demers B, Dumontet C, Gregoire M, Lethiec F, Boue AM, Tonelli D, Pilsudski R, Van Hijfte L, Cailliot C, Vrignaud P, Merlin JL, Oudet P, Arnoux PY, Lassale C. Translational research and Cancer Plan Bull Cancer. 2007 Dec 1;94(12):1107-11.
  • Ouvrir Entz-Werle N, Lavaux T, Metzger N, Stoetzel C, Lasthaus C, Marec P, Kalifa C, Brugieres L, Pacquement H, Schmitt C, Tabone MD, Gentet JC, Lutz P, Babin A, Oudet P, Gaub MP, Perrin-Schmitt F. Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis Neoplasia. 2007 Aug;9(8):678-88.
  • Ouvrir Entz-Werle N, Gaub MP, Lavaux T, Marcellin L, Metzger N, Marec-Berard P, Schmitt C, Brugiere L, Kalifa C, Tabone MD, Pacquement H, Gentet P, Lutz P, Oudet P, Babin A. KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? Int J Cancer. 2007 Jun 1;120(11):2510-6.
  • Ouvrir Brulliard M, Lorphelin D, Collignon O, Lorphelin W, Thouvenot B, Gothie E, Jacquenet S, Ogier V, Roitel O, Monnez JM, Vallois P, Yen FT, Poch O, Guenneugues M, Karcher G, Oudet P, Bihain BE. Nonrandom variations in human cancer ESTs indicate that mRNA heterogeneity increases during carcinogenesis. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7522-7. Epub 2007 Apr 23.
  • Ouvrir Weber JC, Meyer N, Pencreach E, Schneider A, Guerin E, Neuville A, Stemmer C, Brigand C, Bachellier P, Rohr S, Kedinger M, Meyer C, Guenot D, Oudet P, Jaeck D, Gaub MP. Allelotyping analyses of synchronous primary and metastasis CIN colon cancers identified different subtypes. Int J Cancer. 2007 Feb 1;120(3):524-32.
  • Ouvrir Bilbault P, Lavaux T, Launoy A, Gaub MP, Meyer N, Oudet P, Pottecher T, Jaeger A, Schneider F. Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: a cohort study in septic shock patients. Crit Care Med. 2007 Jan;35(1):69-75.
  • Ouvrir Fernandez F, Schneider A, Gaub MP, Lindner V, Oudet P, Lang H, Saussine C, Jacqmin D. [Value of urinary microsatellite analysis in the diagnosis of renal cancer] Prog Urol. 2006 Sep;16(4):429-34.
  • Ouvrir Guenot D, Guerin E, Aguillon-Romain S, Pencreach E, Schneider A, Neuville A, Chenard MP, Duluc I, Du Manoir S, Brigand C, Oudet P, Kedinger M, Gaub MP. Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability. J Pathol. 2006 Apr;208(5):643-52.
  • Ouvrir Entz-Werle N, Stoetzel C, Berard-Marec P, Kalifa C, Brugiere L, Pacquement H, Schmitt C, Tabone MD, Gentet JC, Quillet R, Oudet P, Lutz P, Babin-Boilletot A, Gaub MP, Perrin-Schmitt F. Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. Int J Cancer. 2005 Nov 10;117(3):349-55.
  • Ouvrir Entz-Werle N, Marcellin L, Gaub MP, Guerin E, Schneider A, Berard-Marec P, Kalifa C, Brugiere L, Pacquement H, Schmitt C, Tabone MD, Jeanne-Pasquier C, Terrier P, Dijoud F, Oudet P, Lutz P, Babin-Boilletot A. Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas. J Clin Oncol. 2005 Apr 1;23(10):2248-55.
  • Ouvrir Bilbault P, Lavaux T, Lahlou A, Uring-Lambert B, Gaub MP, Ratomponirina C, Meyer N, Oudet P, Schneider F. Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care. Intensive Care Med. 2004 Mar;30(3):408-15. Epub 2004 Jan 13.
  • Ouvrir Beau-Faller M, Gaub MP, Schneider A, Guerin E, Meyer N, Ducrocq X, Massard G, Gasser B, Kessler R, Weitzenblum E, Wihlm JM, Quoix E, Oudet P. Allelic imbalance at loci containing FGFR, FGF, c-Met and HGF candidate genes in non-small cell lung cancer sub-types, implication for progression. Eur J Cancer. 2003 Nov;39(17):2538-47.
  • Ouvrir Stemmer C, Beau-Faller M, Pencreac'h E, Guerin E, Schneider A, Jaqmin D, Quoix E, Gaub MP, Oudet P. Use of magnetic beads for plasma cell-free DNA extraction: toward automation of plasma DNA analysis for molecular diagnostics. Clin Chem. 2003 Nov;49(11):1953-5.
  • Ouvrir Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN. Cdx1 homeobox gene during human colon cancer progression. Oncogene. 2003 Sep 11;22(39):7913-21.
  • Ouvrir Mousli M, Hopfner R, Abbady AQ, Monte D, Jeanblanc M, Oudet P, Louis B, Bronner C. ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Br J Cancer. 2003 Jul 7;89(1):120-7.
  • Ouvrir Beau-Faller M, Gaub MP, Schneider A, Ducrocq X, Massard G, Gasser B, Chenard MP, Kessler R, Anker P, Stroun M, Weitzenblum E, Pauli G, Wihlm JM, Quoix E, Oudet P. Plasma DNA microsatellite panel as sensitive and tumor-specific marker in lung cancer patients. Int J Cancer. 2003 Jun 20;105(3):361-70.
  • Ouvrir Entz-Werle N, Schneider A, Kalifa C, Voegeli AC, Tabone MD, Marec-Berard P, Marcellin L, Pacquement H, Terrier P, Boutard P, Meyer N, Gaub MP, Lutz P, Babin A, Oudet P. Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. Br J Cancer. 2003 Jun 16;88(12):1925-31.
  • Ouvrir Guerin E, Entz-Werle N, Eyer D, Pencreac'h E, Schneider A, Falkenrodt A, Uettwiller F, Babin A, Voegeli AC, Lessard M, Gaub MP, Lutz P, Oudet P. Modification of topoisomerase genes copy number in newly diagnosed childhood acute lymphoblastic leukemia. Leukemia. 2003 Mar;17(3):532-40.
  • Ouvrir Hopfner R, Mousli M, Oudet P, Bronner C. Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression. Anticancer Res. 2002 Nov-Dec;22(6A):3165-70.
  • Ouvrir Cave-Riant F, Cuillerier B, Beau-Faller M, Martinet N, Alla F, Bronner C, Schneider A, Oudet P, Gaub MP. Association of genetic defects in primary resected lung adenocarcinoma revealed by targeted allelic imbalance analysis. Am J Respir Cell Mol Biol. 2002 Oct;27(4):495-502.
  • Ouvrir Hopfner R, Mousli M, Garnier JM, Redon R, du Manoir S, Chatton B, Ghyselinck N, Oudet P, Bronner C. Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression. Gene. 2001 Mar 21;266(1-2):15-23.
  • Ouvrir Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C. ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. Cancer Res. 2000 Jan 1;60(1):121-8.