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Acteur Jean-Marc EGLY


Dr Jean-Marc EGLY

IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire, Génomique fonctionnelle
1, rue Laurent Fries - BP 10142 - 67404 Illkirch
Tel : +33 3 88 65 34 47, e/m :, web :

Aires d'expertise
Recherche:Biologie Moléculaire, Recherche:Biologie Structurale
Equipe A100 - Dr Jean-Marc EGLY - Expression du Génome et Réparation
  • Ouvrir Frédéric COIN
Comme principal investigateur
Ouvrir2008 - TransReCa (porteur : Jean-Marc EGLY)
Etude de l'instabilité du génome à travers trois maladies génétiques de la réparation prédisposant aux cancers.
Equipe A100 - Dr Jean-Marc EGLY - Expression du Génome et Réparation
Ouvrir2010 - H2A.Z-REP (porteur : Frédéric COIN)
Rôle de l’histone variant H2A.Z dans la réparation de l’ADN et le cancer Role of histone variant H2A.Z in DNA repair and cancer
Equipe A100 - Dr Jean-Marc EGLY - Expression du Génome et Réparation
  • Ouvrir 2008 - ARC - Les modifications des histoires dans la réaction de répartition par excision de nucléotide.
  • Ouvrir Ziani S, Nagy Z, Alekseev S, Soutoglou E, Egly JM, Coin F. Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin. J Cell Biol. 2014 Aug 25. pii: jcb.201403096.
  • Ouvrir Alekseev S, Ayadi M, Brino L, Egly JM, Larsen AK, Coin F. A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum. Chem Biol. 2014 Feb 4. pii: S1074-5521(14)00008-8. doi: 10.1016/j.chembiol.2013.12.014.
  • Ouvrir Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P. Response to Emanuele. J Invest Dermatol. 2014 Jul;134(7):2053-5. doi: 10.1038/jid.2014.67. Epub 2014 Feb 3. - Comment
  • Ouvrir Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P. Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation. J Invest Dermatol. 2014 May;134(5):1408-17. doi: 10.1038/jid.2013.509. Epub 2013 Nov 27.
  • Ouvrir Goffin L, Bour G, Martel F, Nicolau S, Gangloff J, Egly JM, Bayle B. Design and in vivo evaluation of a robotized needle insertion system for small animals. IEEE Trans Biomed Eng. 2013 Aug;60(8):2193-204. doi: 10.1109/TBME.2013.2243728. Epub 2013 Mar 7.
  • Ouvrir Oksenych V, Zhovmer A, Ziani S, Mari PO, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly JM, Coin F. Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. PLoS Genet. 2013;9(7):e1003611. doi: 10.1371/journal.pgen.1003611. Epub 2013 Jul 4.
  • Ouvrir Kristensen U, Epanchintsev A, Rauschendorf MA, Laugel V, Stevnsner T, Bohr VA, Coin F, Egly JM. Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2261-70. doi:
  • Ouvrir Velez-Cruz R, Egly JM. Cockayne syndrome group B (CSB) protein: at the crossroads of transcriptional networks. Mech Ageing Dev. 2013 May-Jun;134(5-6):234-42. doi: 10.1016/j.mad.2013.03.004. Epub 2013 Apr 3. - Review
  • Ouvrir Orioli D, Compe E, Nardo T, Mura M, Giraudon C, Botta E, Arrigoni L, Peverali FA, Egly JM, Stefanini M. XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression. Hum Mol Genet. 2013 Mar 15;22(6):1061-73. doi: 10.1093/hmg/dds508. Epub 2012 Dec
  • Ouvrir Abdulrahman W, Iltis I, Radu L, Braun C, Maglott-Roth A, Giraudon C, Egly JM, Poterszman A. ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E633-42. doi:
  • Ouvrir Velez-Cruz R, Zadorin AS, Coin F, Egly JM. Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E212-20. doi:
  • Ouvrir Zhou X, Khan SG, Tamura D, Ueda T, Boyle J, Compe E, Egly JM, DiGiovanna JJ, Kraemer KH. Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum. Eur J Hum Genet. 2013 Aug;21(8):831-7. doi: 10.1038/ejhg.2012.246. Epub 2012 Dec 12.
  • Ouvrir Le May N, Iltis I, Ame JC, Zhovmer A, Biard D, Egly JM, Schreiber V, Coin F. Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression. Mol Cell. 2012 Dec 14;48(5):785-98. doi: 10.1016/j.molcel.2012.09.021. Epub 2012
  • Ouvrir Le May N, Fradin D, Iltis I, Bougneres P, Egly JM. XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol Cell. 2012 Aug 24;47(4):622-32. doi: 10.1016/j.molcel.2012.05.050. Epub 2012
  • Ouvrir Compe E, Egly JM. TFIIH: when transcription met DNA repair. Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54. doi: 10.1038/nrm3350. - Review
  • Ouvrir Boissel S, Hashimoto S, Rio M, Zarhrate M, Munnich A, Colleaux L, Egly JM. [Early gene expression dysregulation and intellectual disability]. Med Sci (Paris). 2012 Feb;28(2):128-9. Epub 2012 Feb 27. - News
  • Ouvrir Egly JM. [DNA repair mechanisms: from basic biology to genetic pathology]. Bull Acad Natl Med. 2011 Oct;195(7):1689-90.
  • Ouvrir Feuerhahn S, Giraudon C, Martinez-Diez M, Bueren-Calabuig JA, Galmarini CM, Gago F, Egly JM. XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids. Chem Biol. 2011 Aug 26;18(8):988-99.
  • Ouvrir Hashimoto S, Boissel S, Zarhrate M, Rio M, Munnich A, Egly JM, Colleaux L. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. Science. 2011 Aug 26;333(6046):1161-3.
  • Ouvrir Bueren-Calabuig JA, Giraudon C, Galmarini CM, Egly JM, Gago F. Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations. Nucleic Acids Res. 2011 Oct;39(18):8248-57. Epub 2011 Jul 3.
  • Ouvrir Egly JM, Coin F. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst). 2011 Jul 15;10(7):714-21. Epub 2011 May 17. - Review
  • Ouvrir Aprahamian M, Bour G, Akladios CY, Fylaktakidou K, Greferath R, Soler L, Marescaux J, Egly JM, Lehn JM, Nicolau C. Myo-InositolTrisPyroPhosphate treatment leads to HIF-1alpha suppression and eradication of early hepatoma tumors in rats. Chembiochem. 2011 Mar 21;12(5):777-83. doi: 10.1002/cbic.201000619. Epub
  • Ouvrir Milani P, Marilley M, Sanchez-Sevilla A, Imbert J, Vaillant C, Argoul F, Egly JM, Rocca-Serra J, Arneodo A. Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy. PLoS One. 2011 Apr 13;6(4):e18811.
  • Ouvrir Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM. The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. EMBO J. 2011 Feb 2;30(3):468-79. Epub 2010 Dec 14.
  • Ouvrir Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ. A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair. Mol Cell. 2010 Jun 11;38(5):637-48.
  • Ouvrir Le May N, Mota-Fernandes D, Velez-Cruz R, Iltis I, Biard D, Egly JM. NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol Cell. 2010 Apr 9;38(1):54-66.
  • Ouvrir Laugel V, Dalloz C, Durand M, Sauvanaud F, Kristensen U, Vincent MC, Pasquier L, Odent S, Cormier-Daire V, Gener B, Tobias ES, Tolmie JL, Martin-Coignard D, Drouin-Garraud V, Heron D, Journel H, Raffo E, Vigneron J, Lyonnet S, Murday V, Gubser-Mercati D, Funalot B, Brueton L, del Pozo JS, Munoz E, Gennery AR, Salih M, Noruzinia M, Prescott K, Ramos L, Stark Z, Fieggen K, Chabrol B, Sarda P, Edery P, Bloch-Zupan A, Fawcett H, Pham D, Egly JM, Lehmann AR, Sarasin A, Dollfus H. Mutation Update for the CSB/ERCC6 and CSA/ERCC8 Genes Involved in Cockayne Syndrome Hum Mutat. 2010 Feb;31(2):113-26.
  • Ouvrir Kainov DE, Selth LA, Svejstrup JQ, Egly JM, Poterzsman A. Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair (Amst). 2010 Jan 2;9(1):33-9. Epub 2009 Nov 7.
  • Ouvrir Le May N, Egly JM, Coin F. True lies: the double life of the nucleotide excision repair factors in transcription and DNA repair. J Nucleic Acids. 2010 Jul 25;2010. pii: 616342.
  • Ouvrir Ueda T, Compe E, Catez P, Kraemer KH, Egly JM. Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients. J Exp Med. 2009 Dec 21;206(13):3031-46. Epub 2009 Nov 23.
  • Ouvrir Hashimoto S, Egly JM. Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH. Hum Mol Genet. 2009 Oct 15;18(R2):R224-30. - Review
  • Ouvrir Oksenych V, de Jesus BB, Zhovmer A, Egly JM, Coin F. Molecular insights into the recruitment of TFIIH to sites of DNA damage. EMBO J. 2009 Oct 7;28(19):2971-80. Epub 2009 Aug 27.
  • Ouvrir de Jesus BMB, Bjoras M, Coin F, Egly JM. Dissection of the Molecular Defects Caused by Pathogenic Mutations in the DNA Repair Factor XPC Mol Cell Biol. 2008 Dec 1;28(23):7225-35
  • Ouvrir Aguilar-Fuentes J, Fregoso M, Herrera M, Reynaud E, Braun C, Egly JM, Zurita M. p8/TTDA Overexpression Enhances UV-Irradiation Resistance and Suppresses TFIIH Mutations in a Drosophila Trichothiodystrophy Model PLoS Genet. 2008 Nov;4(11):e1000253. Epub 2008 Nov 14.
  • Ouvrir Filippi S, Latini P, Frontini M, Palitti F, Egly JM, Proietti-De-Santis L. CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response. EMBO J. 2008 Oct 8;27(19):2545-56. Epub 2008 Sep 11.
  • Ouvrir Feuerhahn S, Egly JM. Tools to study DNA repair: what's in the box? Trends Genet. 2008 Sep;24(9):467-74. Epub 2008 Jul 31. - Review
  • Ouvrir Kainov DE, Vitorino M, Cavarelli J, Poterszman A, Egly JM. Structural basis for group A trichothiodystrophy Nat Struct Mol Biol. 2008 Sep;15(9):980-4.
  • Ouvrir Coin F, Oksenych V, Mocquet V, Groh S, Blattner C, Egly JM. Nucleotide excision repair driven by the dissociation of CAK from TFIIH. Mol Cell. 2008 Jul 11;31(1):9-20.
  • Ouvrir Laugel V, Dalloz C, Stary A, Cormier-Daire V, Desguerre I, Renouil M, Fourmaintraux A, Velez-Cruz R, Egly JM, Sarasin A, Dollfus H. Deletion of 5 ' sequences of the CSB gene provides insight into the pathophysiology of Cockayne syndrome Eur J Hum Genet. 2008 Mar;16(3):320-7. Epub 2008 Jan 9.
  • Ouvrir Mocquet V, Laine JP, Riedl T, Yajin Z, Lee MY, Egly JM. Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J. 2008 Jan 9;27(1):155-67. Epub 2007 Dec 13.
  • Ouvrir Compe E, Egly JM. [Neurological disorders and trichothiodystrophy: when the transcription process is impaired] Med Sci (Paris). 2007 Dec;23(12):1171-2. - News
  • Ouvrir Compe E, Malerba M, Soler L, Marescaux J, Borrelli E, Egly JM. Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci. 2007 Nov;10(11):1414-22. Epub 2007 Oct 21.
  • Ouvrir Laine JP, Mocquet V, Bonfanti M, Braun C, Egly JM, Brousset P. Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription. DNA Repair (Amst). 2007 Sep 1;6(9):1264-70. Epub 2007 Apr 2.
  • Ouvrir Mocquet V, Kropachev K, Kolbanovskiy M, Kolbanovskiy A, Tapias A, Cai Y, Broyde S, Geacintov NE, Egly JM. The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions. EMBO J. 2007 Jun 20;26(12):2923-32. Epub 2007 May 24.
  • Ouvrir Fregoso M, Laine JP, Aguilar-Fuentes J, Mocquet V, Reynaud E, Coin F, Egly JM, Zurita M. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Mol Cell Biol. 2007 May;27(10):3640-50. Epub 2007 Mar 5.
  • Ouvrir Coin F, Oksenych V, Egly JM. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol Cell. 2007 Apr 27;26(2):245-56.
  • Ouvrir Ito S, Kuraoka I, Chymkowitch P, Compe E, Takedachi A, Ishigami C, Coin F, Egly JM, Tanaka K. XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients. Mol Cell. 2007 Apr 27;26(2):231-43.
  • Ouvrir Vitorino M, Coin F, Zlobinskaya O, Atkinson RA, Moras D, Egly JM, Poterszman A, Kieffer B. Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy. J Mol Biol. 2007 Apr 27;368(2):473-80. Epub 2007 Feb 20.
  • Ouvrir Charlet-Berguerand N, Feuerhahn S, Kong SE, Ziserman H, Conaway JW, Conaway R, Egly JM. RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. EMBO J. 2006 Nov 29;25(23):5481-91. Epub 2006 Nov 16.
  • Ouvrir Mocquet V, Egly JM. Repair by excision - a mechanism in a line of clarification. Biofutur. 2006 Nov;271:40-3.
  • Ouvrir Andressoo JO, Jans J, de Wit J, Coin F, Hoogstraten D, van de Ven M, Toussaint W, Huijmans J, Thio HB, van Leeuwen WJ, de Boer J, Egly JM, Hoeijmakers JH, van der Horst GT, Mitchell JR. Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles. PLoS Biol. 2006 Oct;4(10):e322.
  • Ouvrir D'Errico M, Parlanti E, Teson M, de Jesus BM, Degan P, Calcagnile A, Jaruga P, Bjoras M, Crescenzi M, Pedrini AM, Egly JM, Zambruno G, Stefanini M, Dizdaroglu M, Dogliotti E. New functions of XPC in the protection of human skin cells from oxidative damage. EMBO J. 2006 Sep 20;25(18):4305-15. Epub 2006 Sep 7.
  • Ouvrir Laine JP, Egly JM. When transcription and repair meet: a complex system. Trends Genet. 2006 Aug;22(8):430-6. Epub 2006 Jun 23. - Review
  • Ouvrir Proietti-De-Santis L, Drane P, Egly JM. Cockayne syndrome B protein regulates the transcriptional program after UV irradiation. EMBO J. 2006 May 3;25(9):1915-23. Epub 2006 Apr 6.
  • Ouvrir Laine JP, Egly JM. Initiation of DNA repair mediated by a stalled RNA polymerase IIO. EMBO J. 2006 Jan 25;25(2):387-97. Epub 2006 Jan 12.
  • Ouvrir Coin F, Proietti De Santis L, Nardo T, Zlobinskaya O, Stefanini M, Egly JM. p8/TTD-A as a repair-specific TFIIH subunit. Mol Cell. 2006 Jan 20;21(2):215-26.
  • Ouvrir Laine JP, Mocquet V, Egly JM. TFIIH enzymatic activities in transcription and nucleotide excision repair. Methods Enzymol. 2006;408:246-63.
  • Ouvrir Compe E, Drane P, Laurent C, Diderich K, Braun C, Hoeijmakers JH, Egly JM. Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. Mol Cell Biol. 2005 Jul;25(14):6065-76.